Key result
An artificial neural network prediction model for cardiovascular autonomic dysfunction demonstrated noninferiority to a logistic regression model, with a mean area under the curve of 0.762 versus 0.758 (P <0.001 for noninferiority).
Why the study?
Does an artificial neural network prediction model improve the prediction of cardiovascular autonomic dysfunction compared to logistic regression in a general population?
Cross-Sectional (n=2,092)
Yes
Does an artificial neural network prediction model improve the prediction of cardiovascular autonomic dysfunction compared to logistic regression in a general population?
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Prediction models for CA dysfunction require external validation; leaves open clinical adoption pending prospective testing.
BACKGROUND: This study aimed to develop the artificial neural network (ANN) and multivariable logistic regression (LR) analyses for prediction modeling of cardiovascular autonomic (CA) dysfunction in the general population, and compare the prediction models using the two approaches. METHODS AND MATERIALS: We analyzed a previous dataset based on a Chinese population sample consisting of 2,092 individuals aged 30-80 years. The prediction models were derived from an exploratory set using ANN and LR analysis, and were tested in the validation set. Performances of these prediction models were then compared. RESULTS: Univariate analysis indicated that 14 risk factors showed statistically significant association with the prevalence of CA dysfunction (P<0.05). The mean area under the receiver-operating curve was 0.758 (95% CI 0.724-0.793) for LR and 0.762 (95% CI 0.732-0.793) for ANN analysis, but noninferiority result was found (P<0.001). The similar results were found in comparisons of sensitivity, specificity, and predictive values in the prediction models between the LR and ANN analyses. CONCLUSION: The prediction models for CA dysfunction were developed using ANN and LR. ANN and LR are two effective tools for developing prediction models based on our dataset.
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Tang et al. (2013) conducted a cross-sectional in Cardiovascular Autonomic Dysfunction (n=2,092). Artificial Neural Network (ANN) prediction model vs. Logistic Regression (LR) prediction model was evaluated on Mean area under the receiver-operating curve (AUC) (p=<0.001). An artificial neural network prediction model for cardiovascular autonomic dysfunction demonstrated noninferiority to a logistic regression model, with a mean area under the curve of 0.762 versus 0.758 (P <0.001 for noninferiority).
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