Key result
Patients with coronary artery disease and LVEF <35% showed significant deterioration in ventriculoarterial coupling (Ea/Ees 1.9) compared to controls without ischemic disease (0.6, P<0.05).
Why the study?
Does coronary artery disease with varying degrees of left ventricular ejection fraction affect ventriculoarterial coupling and end-systolic elastance?
Observational (n=20)
Does coronary artery disease with varying degrees of left ventricular ejection fraction affect ventriculoarterial coupling and end-systolic elastance?
Absolute Event Rate: 1.9% vs 0.6%
p-value: p=< 0.05
Patients with coronary artery disease and reduced LVEF exhibit significant deterioration in ventriculoarterial coupling, whereas those with preserved LVEF maintain normal coupling identical to non-ischemic controls.
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CAD with LVEF <35% associates with impaired ventriculoarterial coupling; leaves open prognostic or therapeutic implications.
Kadoi et al. (1998) conducted an observational in Coronary artery disease (n=20). Coronary artery disease with reduced LVEF vs. Normal heart (no ischemic disease) was evaluated on Effective arterial elastance to end-systolic elastance ratio (Ea/Ees) (p=< 0.05). Patients with coronary artery disease and LVEF <35% showed significant deterioration in ventriculoarterial coupling (Ea/Ees 1.9) compared to controls without ischemic disease (0.6, P<0.05).
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