Key result
Optimal filling of the heart 10 minutes before separation from cardiopulmonary bypass prevented the early depression of systolic and diastolic left ventricular function seen with standard separation.
Why the study?
Does optimal filling of the heart before separation from cardiopulmonary bypass prevent early impairment of left ventricular function in patients undergoing coronary artery surgery?
Cohort (n=36)
Does optimal filling of the heart before separation from cardiopulmonary bypass prevent early impairment of left ventricular function in patients undergoing coronary artery surgery?
p-value: p=0.001
Optimal filling of the heart prior to separation from cardiopulmonary bypass prevents the transient depression of systolic and diastolic left ventricular function typically seen early after separation.
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Optimal filling before bypass separation may preserve early LV function; hypothesis-generating and should not yet change practice pending RCTs.
Hert et al. (1996) conducted a cohort in Coronary artery surgery requiring cardiopulmonary bypass (n=36). Optimal filling of the heart 10 min before separation from CPB (Protocol 2) vs. Standard separation procedure (Protocol 1) was evaluated on Systolic function (Ees) and diastolic function (Kc) early after separation from CPB (p=0.001). Optimal filling of the heart 10 minutes before separation from cardiopulmonary bypass prevented the early depression of systolic and diastolic left ventricular function seen with standard separation.
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