Key result
Low dose ionizing radiation (5 cGy) suppressed prostacyclin production in cultured endothelial cells to 53% of control levels, an effect that lasted for 15 minutes.
Why the study?
Does low dose ionizing radiation affect prostacyclin production in cultured endothelial cells?
Does low dose ionizing radiation affect prostacyclin production in cultured endothelial cells?
Low dose ionizing radiation transiently inhibits prostacyclin production in cultured endothelial cells, an effect that can be prevented by the antioxidant alpha-tocopherol.
In an attempt to detect if low doses of ionizing radiation affect the physiological function of blood vessels, the effect of prostacyclin production was examined using cultured endothelial cells. Irradiation with 5 cGy suppressed the production to 53% of the levels in unirradiated control cells. The PGI2 production decreased with an increase in the dose, showing a maximal decrease at 100 cGy without further decrease at 200 cGy. The suppressive effect lasted for 15 min after irradiation and disappeared later. Preincubation with alpha-tocopherol abrogated the suppressive effect completely, although preincubation with ascorbic acid showed little effect. These results suggest that low dose irradiation inhibits the prostacyclin production by changing the cellular membranes transiently.
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Hosoi et al. (1993) studied this question. Low doses of ionizing radiation vs. Unirradiated control cells was evaluated on Prostacyclin (PGI2) production. Low dose ionizing radiation (5 cGy) suppressed prostacyclin production in cultured endothelial cells to 53% of control levels, an effect that lasted for 15 minutes.
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