Why the study?
Does irradiation reduce prostacyclin generation upon PDGF stimulation in vascular segments?
Does irradiation reduce prostacyclin generation upon PDGF stimulation in vascular segments?
Answers are grounded in this paper and cite their sources.
Irradiation decreases prostacyclin generation in vascular segments upon PDGF stimulation, suggesting a mechanism for radiation-induced arterial lesions via haemostatic imbalance.
Experimental and clinical findings demonstrated rather severe arterial lesions occurring in irradiated arteries. It is suggested that a local haemostatic imbalance might be one causative factor. Liberation of PDGF causes smooth-muscle cell proliferation and PGI2 formation by the arterial wall cells, inhibiting in turn further release of PDGF from the alpha granules of the platelets. A decreased ability of irradiated vascular segments to generate PGI2 upon PDGF stimulation described here might cause haemostatic imbalance and subsequent radiation-induced lesions.
No takes yet. Share an insight, caveat, or question.
Sinzinger et al. (1985) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: