April 4, 1986Science
Vasoconstriction: A New Activity for Platelet-Derived Growth Factor
Why the study?
Does Platelet-derived growth factor (PDGF) induce vasoconstriction in rat aortic smooth muscle cells?
Population
Rat aorta strips and cultured rat aortic smooth muscle cells
Comparison
Platelet-derived growth factor (PDGF) vs Angiotensin II
Design
Preclinical
Authors
Discussion
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Implication
PDGF may induce vasoconstriction in rat vascular smooth muscle; leaves open its contribution to human atherosclerotic vasoreactivity.
Key Points
- To examine the effects of platelet-derived growth factor (PDGF) on vasoconstriction in atherosclerotic vessels.
- Examined the contractility of rat aorta strips using PDGF at various concentrations.
- Compared the potency of PDGF to angiotensin II as a vasoconstrictor.
- Measured cytosolic free calcium concentration in cultured rat aortic smooth muscle cells after PDGF exposure.
- PDGF significantly induced concentration-dependent contraction in aortic strips, stronger than angiotensin II.
- PDGF increased cytosolic free calcium concentration in smooth muscle cells, indicating enhanced contractility.
- Findings support a novel role for PDGF in affecting vasoreactivity in atherosclerotic vessels.
Structured PICO
Does Platelet-derived growth factor (PDGF) induce vasoconstriction in rat aortic smooth muscle cells?
P
Population
Rat aorta strips and cultured rat aortic smooth muscle cells
I
Intervention
Platelet-derived growth factor (PDGF)
C
Comparator
Angiotensin II
O
Outcome
Contractility of aortic strips and cytosolic free calcium concentrationsurrogate
PDGF acts as a potent vasoconstrictor, suggesting a new biological activity that may contribute to altered vasoreactivity in atherosclerosis.
Cite This Study
Berk et al. (1986) studied this question.