March 18, 2005Journal of Biological ChemistryOpen Access

Patterns of Gene Expression Differentially Regulated by Platelet-derived Growth Factor and Hypertrophic Stimuli in Vascular Smooth Muscle Cells

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Population

Rat aortic vascular smooth muscle cells, including cells stably expressing constitutively active Galpha…

Comparison

Platelet-derived growth factor (PDGF) stimulation vs Hypertrophic stimulus (constitutively active…

Design

Preclinical

Authors

NKNihal Kaplan-AlbuquerqueVeterans Health Administration YBYolanda E. BogaertUniversity of Colorado Denver VPVicki Van PuttenUniversity of Colorado Anschutz Medical Campus

Discussion

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Implication

May nominate biomarkers for vascular injury; leaves open human relevance and therapeutic implications.

Structured PICO

Population

Rat aortic vascular smooth muscle cells (VSMC), including cells stably expressing constitutively active Galpha(16), gain-of-function H-Ras, or myristoylated Akt, and injured aortas

Intervention

Platelet-derived growth factor (PDGF) stimulation

Comparator

Hypertrophic stimulus (constitutively active Galpha(16))

Outcome

Changes in gene expression profilessurrogate

PDGF and hypertrophic stimuli differentially regulate specific gene families in vascular smooth muscle cells, identifying potential biomarkers for vascular injury.

Cite This Study

Kaplan-Albuquerque et al. (2005) studied this question.

synapsesocial.com/papers/6a1f53d6019c3aaee5834d95 https://doi.org/10.1074/jbc.m500917200

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Patterns of Gene Expression Differentially Regulated by Platelet-derived Growth Factor and Hypertrophic Stimuli in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Patterns of Gene Expression Differentially Regulated by Platelet-derived Growth Factor and Hypertrophic Stimuli in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider