Population
Postconfluent quiescent rat aortic smooth muscle cells (SMCs)
Comparison
Platelet-derived growth factor (PDGF)-BB vs PDGF vehicle, 10% fetal bovine serum, or PDGF-AA
Design
Preclinical
Follow-up
24 hours
Authors
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May promote smooth muscle dedifferentiation in vascular disease; leaves open therapeutic targeting pending human studies.
PDGF-BB globally inhibits the expression of cell-specific proteins characteristic of differentiated smooth muscle cells.
Holycross et al. (1992) studied this question.
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