Population
Porcine aortic smooth muscle cell cultures
Comparison
Platelet-derived growth factor and Somatomedin-C vs Individual growth factors and Sm-C-deficient…
Design
Preclinical
Follow-up
up to 44 hours
Authors
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Hypothesis-generating for PDGF-Sm-C synergy in vascular smooth muscle; leaves open human disease relevance.
PDGF and Sm-C act synergistically as potent mitogens for porcine aortic smooth muscle cells, with Sm-C being required to initiate DNA synthesis.
David R. Clemmons (1985) studied this question.
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