Population
Vascular smooth muscle cells (VSMC) isolated from either thoracic or abdominal pig aorta
Comparison
Stimulation with PDGF isoforms alone, or… vs Different PDGF isoforms and different regional…
Design
Preclinical
Authors
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Regional PDGF signaling differences in porcine aorta may reflect vascular heterogeneity; leaves open relevance to human disease or therapy.
Regional differences exist in the distribution of PDGF-A- and B-type receptors in porcine aorta, leading to distinct mechanisms of calcium signaling upon activation.
Diliberto et al. (1991) studied this question.
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