Why the study?
Does platelet-derived growth factor increase calcium channel currents in vascular smooth muscle cells?
Population
Single vascular smooth muscle cells isolated from rabbit ear arteries
Comparison
Platelet-derived growth factor, AB and BB isoforms vs Baseline or cells pre-incubated with tyrosine…
Design
Preclinical
Authors
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May link PDGF-tyrosine kinase signaling to VSMC calcium currents; hypothesis-generating for human vascular disease.
Does platelet-derived growth factor increase calcium channel currents in vascular smooth muscle cells?
PDGF increases calcium channel currents in vascular smooth muscle cells, likely via a tyrosine kinase-dependent mechanism.
Wijetunge et al. (1995) studied this question.
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