September 1, 1989Journal of Cellular Physiology

Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover

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Population

Swiss 3T3 cells and human dermal fibroblasts

Design

Preclinical

Authors

MHMarkus HosangRoche (Switzerland)MRMarianne RougeRoche (Switzerland)BWBeat WipfRoche (Switzerland)

Discussion

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Implication

Receptor expression dictates PDGF isoform responses in animal cells; leaves open translation to human cardiovascular disease.

Structured PICO

Population

Swiss 3T3 cells and human dermal fibroblasts

Intervention

Platelet-derived growth factor (PDGF) isoforms (AA, BB, AB)

Outcome

DNA synthesis, inositol phospholipid metabolism, and chemotaxissurrogate

Differences in cellular responsiveness to PDGF isoforms are primarily due to varying levels of surface expression of isoform-specific receptors rather than intrinsic activity differences.

Cite This Study

Hosang et al. (1989) studied this question.

synapsesocial.com/papers/6a8b914cf19228bbb2fb5572 https://doi.org/10.1002/jcp.1041400322

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Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider