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December 1, 1995Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Expression and Function of a Recombinant PDGF B Gene in Porcine Arteries

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Population

Porcine arteries in vivo

Comparison

Direct gene transfer of a recombinant PDGF B gene vs Control transfected arteries

Design

Preclinical

Follow-up

21 days

Authors

VPVincent J. PompiliThe Ohio State University Wexner Medical CenterDGDavid J. GordonUniversity of IowaHSHong SanHarbin Medical University

Discussion

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Implication

PDGF-B drives neointimal expansion in porcine arteries; hypothesis-generating for targeted inhibition in human restenosis.

Structured PICO

P
Population
Porcine arteries in vivo
I
Intervention
Direct gene transfer of a recombinant PDGF B gene
C
Comparator
Control transfected arteries
O
Outcome
Intimal thickening, smooth muscle cell proliferation and migration, extracellular matrix synthesis, and inflammatory cell infiltrationsurrogate

PDGF B gene expression promotes intimal expansion in porcine arteries through smooth muscle cell proliferation, migration, and extracellular matrix synthesis.

Cite This Study

Pompili et al. (1995) studied this question.

synapsesocial.com/papers/6a6f59dffe4101aa97dfc247https://doi.org/10.1161/01.atv.15.12.2254
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis1990 · 584 citations
  2. 2A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells <i>In Vitro</i>1974 · 1,855 citations
  3. 3Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.1994 · 412 citations
  4. 4Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids.1986 · 91 citations
  5. 5Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury.1986 · 392 citations