Key result
PDGF-BB treatment of pulmonary artery smooth muscle cells induced miR-376b upregulation, which mediated BMPR2 downregulation and promoted cell proliferation.
Population
Cultured primary rat pulmonary arterial smooth muscle cells (RPASMCs) (≤4 passage)
Comparison
Platelet-derived growth factor BB 30 ng/ml… vs 0 h (no PDGF-BB exposure) or vehicle treatment
Design
Preclinical
Authors
Loading...
miR-376b may mediate pulmonary vascular proliferation; hypothesis-generating and leaves open in vivo relevance.
Integrated multi-omics analysis reveals that PDGF-BB promotes pulmonary artery smooth muscle cell proliferation by upregulating miR-376b, which in turn downregulates BMPR2, highlighting a novel crosstalk mechanism in PAH pathogenesis.
Chen et al. (2016) studied Pulmonary arterial hypertension (in vitro model). PDGF-BB vs. Untreated cells (0 h) was evaluated on Differentially expressed mRNAs and proteins. PDGF-BB treatment of pulmonary artery smooth muscle cells induced miR-376b upregulation, which mediated BMPR2 downregulation and promoted cell proliferation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: