Why the study?
Does transgenic overexpression of PDGF-A and PDGF-B induce cardiac fibrosis and hypertrophy in mice?
Does transgenic overexpression of PDGF-A and PDGF-B induce cardiac fibrosis and hypertrophy in mice?
Overexpression of PDGF-A induces severe cardiac fibrosis mediated by PDGFRα, highlighting the potential role of endogenous PDGFRα agonists in the pathogenesis of cardiac fibrosis.
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PDGF-A overexpression drives lethal fibrosis in mice; leaves open PDGFRα as a therapeutic target in human cardiac fibrosis.
Gallini et al. (2016) studied this question.
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