January 21, 2008Developmental DynamicsOpen Access

PDGF‐B signaling is important for murine cardiac development: Its role in developing atrioventricular valves, coronaries, and cardiac innervation

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Population

Pdgf-b-/- and Pdgfr-beta-/- mouse embryos at different embryonic stages

Comparison

Genetic knockout of Pdgf-b or Pdgfr-beta vs Wild-type mouse embryos

Design

Preclinical

Authors

NANynke M. S. van den AkkerMaastricht University LWLeah C.J. Winkel MNMaya H. NisanciogluMatrix Research (United States)

Discussion

Member takes

Implication

PDGF-B/PDGFR-beta signaling is essential for murine cardiac septation and vascularization; hypothesis-generating for human congenital heart disease with no immediate clinical implications.

Structured PICO

Population

Pdgf-b-/- and Pdgfr-beta-/- mouse embryos at different embryonic stages

Intervention

Genetic knockout of Pdgf-b or Pdgfr-beta

Comparator

Wild-type mouse embryos

Outcome

Structural aberrations in cardiac development (assessed via immunohistochemical staining for alphaSMA, periostin, ephrinB2, EphB4, VEGFR-2, Dll1, and NCAM)

PDGF-B/PDGFR-beta signaling plays a crucial role in murine cardiac development, specifically in the contribution of epicardium-derived cells and cardiac neural crest lineages.

Cite This Study

Akker et al. (2008) studied this question.

synapsesocial.com/papers/6a9a87dd9ea0d0cee23b2b07 https://doi.org/10.1002/dvdy.21436

Topics

Congenital heart disease adults

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Implication

PDGF-B/PDGFR-beta signaling is essential for murine cardiac septation and vascularization; hypothesis-generating for human congenital heart disease with no immediate clinical implications.

PDGF‐B signaling is important for murine cardiac development: Its role in developing atrioventricular valves, coronaries, and cardiac innervation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

PDGF‐B signaling is important for murine cardiac development: Its role in developing atrioventricular valves, coronaries, and cardiac innervation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider