What is the clinical evidence from this study?

Population: Heart Failure. Intervention: PDGFRβ activation via tamoxifen. Primary outcome: Cardiac function and global longitudinal strain (GLS).

October 9, 2025Circulation Research

Abstract Thu148: PDGFRβ Expression Marks a Multipotent Cardiac Fibroblast Population that Drives Fibrosis and Inflammation in Heart Failure

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Key result

Fibroblast PDGFRβ activation impairs GLS and drives myocardial fibrosis in mice.

Key Points

Activated PDGFRβ in cardiac fibroblasts promotes fibrosis and inflammation, leading to heart dysfunction.
Echocardiographic analysis revealed elevated global longitudinal strain in Tg mice but no significant cardiac function changes.
Transgenic mice with PDGFRβ activation in cardiac fibroblasts showed increased myocardial fibrosis and inflammation.
Modulating PDGFRβ expression could provide new therapeutic approaches for managing chronic heart failure.

Structured PICO

Population

Transgenic mice with an inducible PDGFRβ-activating mutation in cardiac fibroblasts fed a tamoxifen-containing diet for 8 weeks.

Intervention

Tamoxifen-containing diet for 8 weeks to activate PDGFRβ signaling in cardiac fibroblasts

Outcome

Cardiac function and global longitudinal strain (GLS) via echocardiography, myocardial interstitial fibrosis, cardiomyocyte hypertrophy, and macrophage abundancesurrogate

Discussion

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Implication

Activation of PDGFRβ in cardiac fibroblasts is sufficient to induce early left ventricular dysfunction, fibrosis, and inflammation in a mouse model, suggesting a potential therapeutic target for chronic heart failure.

Cite This Study

Hamid et al. (2025) studied Heart Failure. PDGFRβ activation via tamoxifen was evaluated on Cardiac function and global longitudinal strain (GLS). PDGFRβ activation in cardiac fibroblasts of transgenic mice elevated global longitudinal strain and increased myocardial interstitial fibrosis, cardiomyocyte hypertrophy, and macrophage abundance.

synapsesocial.com/papers/68e77f09d1c187e1c108fc16 https://doi.org/10.1161/res.137.suppl_1.thu148

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Abstract Thu148: PDGFRβ Expression Marks a Multipotent Cardiac Fibroblast Population that Drives Fibrosis and Inflammation in Heart Failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Abstract Thu148: PDGFRβ Expression Marks a Multipotent Cardiac Fibroblast Population that Drives Fibrosis and Inflammation in Heart Failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider