Why the study?
The role of fibroblasts in maintaining the basal extracellular matrix network and in fibrosis in vivo is poorly understood.
Does genetic ablation of fibroblasts improve cardiac function after injury in adult mice?
Does genetic ablation of fibroblasts improve cardiac function after injury in adult mice?
Controlled reduction of cardiac fibroblasts in adult mice preserves cardiac function after injury, suggesting that targeting fibroblasts may offer cardioprotective therapeutic value in heart disease.
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Supports preclinical fibroblast targeting for cardiac protection; leaves open human translation and safety.
Kuwabara et al. (2021) studied this question.
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