Key result
Genetic ablation of fibroblast activation protein alpha attenuated left ventricular dilation and decreased the infarct expansion index (3.5 vs 5.7, p<0.05) at 28 days after myocardial infarction.
Why the study?
Regulating fibroblast activation may optimize extracellular matrix deposition and myocardial stiffness, but whether FAP depletion protects against LV remodeling after MI was unknown.
Does genetic ablation of fibroblast activation protein alpha attenuate left ventricular remodeling after myocardial infarction in mice?
Population
Homozygous FAP deficient mice (n = 51) and wild type mice (n = 55) after MI, plus healthy mice
Comparison
FAP-deficient mice vs wild type mice
Design
Animal experimental study
Authors
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FAP inhibition may limit post-MI remodeling; confirms protective role in mice and leaves translation to patients open.
Does genetic ablation of fibroblast activation protein alpha attenuate left ventricular remodeling after myocardial infarction in mice?
Absolute Event Rate: 3.5% vs 5.7%
p-value: p=<0.05
Genetic ablation of FAP attenuates left ventricular dilation and promotes a thicker scar after myocardial infarction in mice, suggesting a potential target for modulating post-MI remodeling.
Hoffmann et al. (2021) studied Myocardial infarction (n=135). Genetic ablation of fibroblast activation protein alpha (FAP-KO) vs. Wildtype (WT) mice was evaluated on Infarct expansion index at 28 days after myocardial infarction (p=<0.05). Genetic ablation of fibroblast activation protein alpha attenuated left ventricular dilation and decreased the infarct expansion index (3.5 vs 5.7, p<0.05) at 28 days after myocardial infarction.
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