July 20, 2010Journal of Biological ChemistryOpen Access

Cardiac Restricted Overexpression of Membrane Type-1 Matrix Metalloproteinase Causes Adverse Myocardial Remodeling following Myocardial Infarction

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Population

Mice with induced myocardial infarction

Comparison

Cardiac restricted MT1-MMP overexpression vs Wild type (WT) mice

Design

Preclinical

Authors

FSFrancis G. SpinaleHeart Failure & Transplant RMRupak MukherjeeMedical University of South Carolina JZJuozas A. ZavadzkasUniversity of South Carolina

Discussion

Member takes

Implication

MT1-MMP overexpression worsens post-MI outcomes in mice; hypothesis-generating for therapeutic targeting in humans.

Structured PICO

Population

Mice with induced myocardial infarction (n=118 total; 58 with cardiac restricted MT1-MMP overexpression and 60 wild type)

Intervention

Cardiac restricted MT1-MMP overexpression (MT1-MMPexp)

Comparator

Wild type (WT) mice

Outcome

Post-MI survival and left ventricular ejection fractionsurrogate

Cardiac restricted overexpression of MT1-MMP worsens survival, LV function, and fibrosis post-myocardial infarction in mice, likely through increased processing of pro-fibrotic signaling molecules.

Cite This Study

Spinale et al. (2010) studied this question.

synapsesocial.com/papers/6a6ff9908031ec7bb1dc0b83 https://doi.org/10.1074/jbc.m110.158196

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Cardiac Restricted Overexpression of Membrane Type-1 Matrix Metalloproteinase Causes Adverse Myocardial Remodeling following Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac Restricted Overexpression of Membrane Type-1 Matrix Metalloproteinase Causes Adverse Myocardial Remodeling following Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider