Why the study?
Excessive cardiac fibrosis is an important factor in heart failure progression, but clinical interventions and therapies that target fibrosis remain limited.
Does adoptive transfer of CAR-T cells targeting fibroblast activation protein reduce cardiac fibrosis and restore function in mice with cardiac injury?
Population
Mice with cardiac injury and pathological cardiac fibrosis
Comparison
Adoptive transfer of CAR T cells targeting fibroblast activation protein
Design
Preclinical animal and translational gene expression study
Authors
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Should not change clinical practice; hypothesis-generating for CAR-T targeting fibroblast activation protein in cardiac fibrosis.
Does adoptive transfer of CAR-T cells targeting fibroblast activation protein reduce cardiac fibrosis and restore function in mice with cardiac injury?
CAR-T cell therapy targeting fibroblast activation protein provides proof-of-principle for an immunotherapeutic approach to reduce pathological cardiac fibrosis and restore cardiac function.
Aghajanian et al. (2019) studied this question.
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