Why the study?
FAP is associated with human coronary atherosclerotic plaques, but its causal role in atherosclerosis remains unknown.
Does constitutive Fap deletion reduce plaque formation in atherosclerosis-prone mice?
Population
Atherosclerosis-prone Apoe or Ldlr knockout mice
Comparison
Constitutive Fap deletion vs Fap-intact controls
Design
Preclinical animal study
Authors
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Should not change practice; leaves open FAP targeting to limit human atherosclerosis and enhance plaque stability.
Does constitutive Fap deletion reduce plaque formation in atherosclerosis-prone mice?
Constitutive deletion of fibroblast activation protein decreases experimental atherosclerosis progression and increases features of plaque stability.
Stein et al. (2020) studied this question.
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