Key result
Basic fibroblast growth factor significantly inhibited PDGF-BB-induced smooth muscle cell migration and proliferation in vitro, an effect mediated by both PDGF-Ralpha and bFGF receptor.
Population
Rat aorta smooth muscle cells (SMC) in vitro
Comparison
Simultaneous exposure to platelet-derived growth… vs Exposure to PDGF-BB alone or with non-inhibitory…
Design
Preclinical
Authors
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No direct clinical implications yet; leaves open bFGF's therapeutic potential in modulating post-injury vascular remodeling.
In vitro, bFGF significantly inhibits PDGF-BB-induced smooth muscle cell migration and proliferation, providing insights into vascular wall modulation after endovascular injury.
Facchiano et al. (2000) studied this question. Basic fibroblast growth factor (bFGF) was evaluated on Smooth muscle cell migration and proliferation. Basic fibroblast growth factor significantly inhibited PDGF-BB-induced smooth muscle cell migration and proliferation in vitro, an effect mediated by both PDGF-Ralpha and bFGF receptor.
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