November 18, 1997Circulation
Primate Smooth Muscle Cell Migration From Aortic Explants Is Mediated by Endogenous Platelet-Derived Growth Factor and Basic Fibroblast Growth Factor Acting Through Matrix Metalloproteinases 2 and 9
Why the study?
Do MMP2, MMP9, bFGF, or PDGF play a role in smooth muscle cell migration from medial explants of baboon aorta?
Population
Baboon aortic medial explants (primate smooth muscle cells)
Comparison
Neutralizing antibodies to MMP2, proMMP9, bFGF… vs Control explants cultured in serum-free medium…
Design
Preclinical
Authors
Discussion
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Implication
Remains preclinical; leaves open whether MMP/PDGF pathway inhibition alters human vascular remodeling.
Structured PICO
Do MMP2, MMP9, bFGF, or PDGF play a role in smooth muscle cell migration from medial explants of baboon aorta?
P
Population
Baboon aortic medial explants (primate smooth muscle cells)
I
Intervention
Neutralizing antibodies to MMP2, proMMP9, bFGF, and PDGF receptor subunits; addition of bFGF, PDGF-BB, and PDGF-AA
C
Comparator
Control explants cultured in serum-free medium with insulin, transferrin, and ovalbumin
O
Outcome
Smooth muscle cell migration from the aortic explantssurrogate
Smooth muscle cell migration from primate aortic explants is dependent on endogenous MMP2, MMP9, PDGF, and bFGF, providing mechanistic insights into arterial remodeling.
Cite This Study
Kenagy et al. (1997) studied this question.