Key result
Vascular smooth muscle cell migration to PDGF-BB was lower in internal mammary artery than saphenous vein, which is at least in part related to lower activity of the Rho/ROCK pathway.
Population
Vascular smooth muscle cells and endothelial cells isolated from human internal mammary artery and saphenous…
Comparison
PDGF-BB stimulation, with or without… vs Comparison between cells from internal mammary…
Design
Preclinical
Authors
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Supports Rho/ROCK targeting in vein graft disease models; leaves open whether modulation improves human bypass outcomes.
The reduced migratory capacity of vascular smooth muscle cells from the internal mammary artery compared to the saphenous vein, mediated by lower Rho/ROCK pathway activity, provides a mechanistic basis for the superior long-term patency of arterial bypass grafts.
Weiß et al. (2007) studied this question. Internal mammary artery (MA) vascular smooth muscle cells vs. Saphenous vein (SV) vascular smooth muscle cells was evaluated on Migration to PDGF-BB. Vascular smooth muscle cell migration to PDGF-BB was lower in internal mammary artery than saphenous vein, which is at least in part related to lower activity of the Rho/ROCK pathway.
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