Why the study?
Does increased static pressure promote migration of vascular smooth muscle cells via the Rho-kinase pathway?
Population
Rat vascular smooth muscle cells cultured on chambers coated on fibronectin, vitronectin, laminin, or type…
Comparison
Static pressure at 90 and 180 mm Hg, with or… vs Pressure-free conditions
Design
Preclinical
Follow-up
72 hours
Authors
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Should not alter hypertension management; leaves open Rho-kinase targeting in vascular remodeling.
Does increased static pressure promote migration of vascular smooth muscle cells via the Rho-kinase pathway?
Increased static pressure promotes vascular smooth muscle cell migration through integrin/Rho-kinase signaling, highlighting a potential therapeutic target for hypertensive vascular diseases.
Onoue et al. (2008) studied this question.
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