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Actin networks cross-linked by natural linkers -actinin and filamin are generated in giant vesicles by polymerization through ionophore-mediated influx of Mg^2+. -actinin induces the formation of randomly linked networks at 25 ^ which transform at <15 ^ into spiderweblike gels or ringlike bundles depending on the vesicle size. Muscle filamin forms ringlike structures under all experimental conditions which can supercoil by subsequent Mg^2+ addition. The polymorphism is rationalized in terms of recent models of bivalent ion coupled semiflexible polyelectrolytes and by considering the topology of the linkers.
Limozin et al. (Mon,) studied this question.