The costs and cost-effectiveness of an integrated sepsis treatment protocol

CONTEXT: Sepsis is associated with high mortality and treatment costs. International guidelines recommend the implementation of integrated sepsis protocols; however, the true cost and cost-effectiveness of these are unknown. OBJECTIVE: To assess the cost-effectiveness of an integrated sepsis protocol, as compared with conventional care. DESIGN: Prospective cohort study of consecutive patients presenting with septic shock and enrolled in the institution's integrated sepsis protocol. Clinical and economic outcomes were compared with a historical control cohort. SETTING: Beth Israel Deaconess Medical Center. PATIENTS: Overall, 79 patients presenting to the emergency department with septic shock in the treatment cohort and 51 patients in the control group. INTERVENTIONS: An integrated sepsis treatment protocol incorporating empirical antibiotics, early goal-directed therapy, intensive insulin therapy, lung-protective ventilation, and consideration for drotrecogin alfa and steroid therapy. MAIN OUTCOME MEASURES: In-hospital treatment costs were collected using the hospital's detailed accounting system. The cost-effectiveness analysis was performed from the perspective of the healthcare system using a lifetime horizon. The primary end point for the cost-effectiveness analysis was the incremental cost per quality-adjusted life year gained. RESULTS: Mortality in the treatment group was 20. 3% vs. 29. 4% in the control group (p =. 23). Implementing an integrated sepsis protocol resulted in a mean increase in cost of approximately 8, 800 per patient, largely driven by increased intensive care unit length of stay. Life expectancy and quality-adjusted life years were higher in the treatment group; 0. 78 and 0. 54, respectively. The protocol was associated with an incremental cost of 11, 274 per life-year saved and a cost of 16, 309 per quality-adjusted life year gained. CONCLUSIONS: In patients with septic shock, an integrated sepsis protocol, although not cost-saving, appears to be cost-effective and compares very favorably to other commonly delivered acute care interventions.