Key result
Judicious treatment of elevated blood pressure in the elderly reduces the risk of cardiovascular morbidity and mortality, with low-dose diuretics recommended as initial therapy.
Why the study?
Does treatment of elevated blood pressure reduce cardiovascular morbidity and mortality in elderly patients with hypertension?
Does treatment of elevated blood pressure reduce cardiovascular morbidity and mortality in elderly patients with hypertension?
Treating hypertension in the elderly, particularly with low-dose diuretics, effectively reduces cardiovascular morbidity and mortality without significantly compromising quality of life.
Supports judicious BP lowering with low-dose diuretics in elderly; leaves open optimal targets and agent comparisons.
BACKGROUND: There are now more than 31 million people 65 years of age or older in the United States, at least half of whom have systolic blood pressure 140 mm Hg or higher or diastolic blood pressure 90 mm Hg or higher or both. By the year 2050, 16 million Americans will be over age 85. OBJECTIVE: To review the current data and recommendations regarding treating hypertension in elderly patients. SUMMARY: Randomized clinical trials have dispelled some of the myths that surround treatment of hypertension in the elderly by showing that judicious treatment of elevated blood pressure, both systolic and diastolic, will reduce the risk of cardiovascular morbidity and mortality, with an acceptable trade-off in terms of side effects and without sacrificing quality of life. CONCLUSIONS: Because most of the trials have used a diuretic as initial therapy, it is recommended that one of these agents be prescribed in low doses if life-style modifications do not reduce blood pressure to acceptable levels, unless there is a contraindication to diuretics or an indication for another class of agents.
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Vidt et al. (1995) conducted a review in Hypertension. Antihypertensive therapy (diuretics) was evaluated on Cardiovascular morbidity and mortality. Judicious treatment of elevated blood pressure in the elderly reduces the risk of cardiovascular morbidity and mortality, with low-dose diuretics recommended as initial therapy.
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