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April 1, 1993Journal of General Virology

Sequence variability in the 5' non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity

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Key result

Phylogenetic analysis of the 5' non-coding region of HCV identified a new virus type (type 4), widespread in Africa, and revealed that sequence variability is constrained by secondary RNA structures.

Population

Geographically dispersed variants of hepatitis C virus (HCV)

Design

Preclinical

Authors

PSPeter SimmondsGoethe University FrankfurtFMF. McOmishRiyadh Armed Forces HospitalPYP.L. YapScottish National Blood Transfusion Service

Discussion

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Implication

May inform African HCV surveillance; leaves open clinical impact of type 4.

Structured PICO

P
Population
Geographically dispersed variants of hepatitis C virus (HCV)
E
Exposure
Analysis of nucleotide sequence variability in the 5' non-coding region (5' NCR)
O
Outcome
Identification of new virus types and secondary structure constraints

Identifies a new HCV genotype (type 4) and demonstrates that 5' NCR sequence variability is constrained by RNA secondary structure, enabling a rapid restriction enzyme cleavage method for virus typing.

Cite This Study

Simmonds et al. (1993) studied Hepatitis C virus. Sequence variability analysis of the 5' non-coding region was evaluated on Identification of HCV types and secondary structure constraints. Phylogenetic analysis of the 5' non-coding region of HCV identified a new virus type (type 4), widespread in Africa, and revealed that sequence variability is constrained by secondary RNA structures.

synapsesocial.com/papers/6a22fa1f3bf314e836cb1b08https://doi.org/10.1099/0022-1317-74-4-661
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Also Consider

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