Population
Genomic RNA from the human prototype strain H of the hepatitis C virus (HCV-H)
Comparison
Molecular cloning and sequencing vs American isolate HCV-1 and Japanese isolates…
Design
Preclinical
Key result
Genomic sequencing of the hepatitis C virus prototype strain H revealed 96% amino acid identity with the American isolate HCV-1 but only 84.9% with Japanese isolates.
Authors
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HCV heterogeneity may require adjusted diagnostics; leaves open subtype effects on outcomes and vaccines.
The cloning and sequencing of HCV-H reveals significant heterogeneity between American and Japanese isolates, suggesting the existence of at least two genomic subtypes of HCV.
Inchauspé et al. (1991) studied Hepatitis C virus. Genomic sequencing of HCV-H vs. American and Japanese isolates (HCV-1, HCV-J, HCV-BK) was evaluated on Genomic sequence and amino acid identity. Genomic sequencing of the hepatitis C virus prototype strain H revealed 96% amino acid identity with the American isolate HCV-1 but only 84.9% with Japanese isolates.