Key result
Molecular cloning of the human hepatitis A virus revealed a 7478-nucleotide genome encoding a polyprotein with structural homologies to poliovirus.
Population
Human hepatitis A virus (HAV) RNA genome
Comparison
Molecular cloning and nucleotide sequencing vs Other picornaviruses (including poliovirus)
Design
Preclinical
Authors
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Provides foundational HAV sequence data; leaves open clinical translation of picornavirus homologies.
The study determined the complete nucleotide sequence of the human hepatitis A virus genome, revealing its structural relationship to other picornaviruses.
Najarian et al. (1985) studied Hepatitis A virus. Molecular cloning and sequencing vs. Other picornaviruses (e.g., poliovirus) was evaluated on Viral genome length and primary structure. Molecular cloning of the human hepatitis A virus revealed a 7478-nucleotide genome encoding a polyprotein with structural homologies to poliovirus.
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