April 1, 1985Proceedings of the National Academy of SciencesOpen Access

Sequence analysis of hepatitis A virus cDNA coding for capsid proteins and RNA polymerase.

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Population

Hepatitis A virus (HAV) genome

Comparison

Sequence analysis of cDNA coding for capsid… vs Analogous regions of poliovirus…

Design

Preclinical

Authors

BBBahige M. BaroudyCincinnati Children's Hospital Medical Center JTJohn R. TicehurstJohns Hopkins University TMThomas A. MieleLehigh Valley Hospital

Discussion

Member takes

Implication

Distinguishes HAV from other picornaviruses; leaves open targeted diagnostics and evolutionary questions.

Structured PICO

Population

Hepatitis A virus (HAV) genome

Intervention

Sequence analysis of cDNA coding for capsid proteins and RNA polymerase

Comparator

Analogous regions of poliovirus, encephalomyocarditis virus, and foot and mouth disease virus

Outcome

Nucleotide sequence and predicted amino acid sequence homology

The study identifies the genomic organization of HAV, confirming it codes for capsid proteins and RNA polymerase, though it is not closely related to other picornaviruses.

Cite This Study

Baroudy et al. (1985) studied this question.

synapsesocial.com/papers/6a708f6c8031ec7bb1dc6d57 https://doi.org/10.1073/pnas.82.7.2143

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Sequence analysis of hepatitis A virus cDNA coding for capsid proteins and RNA polymerase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sequence analysis of hepatitis A virus cDNA coding for capsid proteins and RNA polymerase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider