May 1, 1986Journal of VirologyOpen Access

Structure of the hepatitis A virion: peptide mapping of the capsid region

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Population

Hepatitis A virus (HAV) from persistently infected cell cultures; rabbits immunized with synthetic peptides

Design

Preclinical

Authors

Discussion

Should not yet change HAV practice; extends capsid mapping in animal models.

Population

Hepatitis A virus (HAV) from persistently infected cell cultures; rabbits immunized with synthetic peptides

Intervention

Synthetic peptides corresponding to selected regions of HAV capsid polypeptides coupled to keyhole limpet hemocyanin

Outcome

Identification of the gene order and molecular weights of HAV P1 region gene productssurrogate

The study mapped the capsid region of the hepatitis A virion, identifying the molecular weights and gene order of its major polypeptides.

Wheeler et al. (1986) studied this question.

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