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March 1, 2000Journal of Gastroenterology and Hepatology

Molecular biology of hepatitis A virus: Significance of various substitutions in the hepatitis A virus genome

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Population

Hepatitis A virus (HAV)

Design

Review

Authors

OYOsamu YokosukaChiba University

Discussion

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Implication

HAV 2B/2C substitutions may refine subspecies analysis; extends molecular mapping but leaves clinical translation open.

Structured PICO

P
Population
Hepatitis A virus (HAV)

Understanding the molecular biology and genomic substitutions of HAV is important for analyzing differences in HAV subspecies across clinical conditions.

Cite This Study

Osamu Yokosuka (2000) studied this question.

synapsesocial.com/papers/6a825644f10a9fcdd646cc24https://doi.org/10.1046/j.1440-1746.2000.02141.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prolonged Fecal Excretion of Hepatitis A Virus in Adult Patients With Hepatitis A As Determined by Polymerase Chain Reaction1996 · 84 citations
  2. 2Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses1987 · 385 citations
  3. 3Utilization of Chimeras between Human (HM-175) and Simian (AGM-27) Strains of Hepatitis A Virus To Study the Molecular Basis of Virulence1998 · 28 citations
  4. 4Coding Sequences Enhance Internal Initiation of Translation by Hepatitis A Virus RNA In Vitro1998 · 26 citations
  5. 5Genetic relatedness of hepatitis A virus strains recovered from different geographical regions1992 · 498 citations