An Autopsy Case of Hypertrophic Cardiomyopathy with Pathological Findings Suggesting Chronic Myocarditis.
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Key result
Autopsy of a 68-year-old woman with hypertrophic cardiomyopathy revealed extensive myocardial fibrosis and significant lymphocytic infiltration with a CD4 to CD8 ratio of 3.8, suggesting an undefined inflammatory process.
Population
1 68-year-old Japanese woman with hypertrophic cardiomyopathy (HCM) and diabetes mellitus
Design
Case_report
Follow-up
10 years
Authors
Discussion
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Member takes
Implication
Single autopsy case does not support practice change in HCM; hypothesis-generating for inflammatory role in fibrosis.
Study Design
Type
Case Report (n=1)
Multicenter
No
Structured PICO
P
Population
A 68-year-old woman with hypertrophic cardiomyopathy followed for 10 years who underwent trans-aortic myectomy and later autopsy.
E
Exposure
Trans-aortic myectomy of the interventricular septum followed by autopsy 10 years later
O
Outcome
Pathological findings of the myocardium including fibrosis, cell infiltration, and lymphocyte subsetssurrogate
This case report suggests that an undefined inflammatory process, characterized by CD4-predominant lymphocytic infiltration, may contribute to myocardial fibrosis in hypertrophic cardiomyopathy.
Limitations
- Single case report
- Unclear whether the CD4/CD8 ratio is specific for infiltrating cells in hypertrophic cardiomyopathy
Cite This Study
Kawano et al. (1994) conducted a case report in Hypertrophic Cardiomyopathy (n=1). Pathological examination was evaluated on Pathological findings (myocardial fibrosis and cell infiltration). Autopsy of a 68-year-old woman with hypertrophic cardiomyopathy revealed extensive myocardial fibrosis and significant lymphocytic infiltration with a CD4 to CD8 ratio of 3.8, suggesting an undefined inflammatory process.
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