Key result
Costamere components, including melusin and nNOS, act as a sarcolemmal signaling hub integrating mechanical and humoral stimuli to regulate muscle mass and contribute to muscle atrophy development.
Why the study?
Targeting the atrogene pathway has shown only partial effects in antagonizing muscle atrophy, suggesting other master regulators, including costamere components, may independently contribute.
Design
Review
Authors
Loading...
Hypothesis-generating for costamere-targeted interventions in atrophy; leaves open clinical translation pending prospective trials.
This review highlights the crucial role of costamere components, such as melusin and nNOS, as master regulators in the development of muscle atrophy.
Gorza et al. (2021) conducted a review in Muscle atrophy. Costamere components and master regulators was evaluated. Costamere components, including melusin and nNOS, act as a sarcolemmal signaling hub integrating mechanical and humoral stimuli to regulate muscle mass and contribute to muscle atrophy development.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: