Key result
Hyperhomocysteinemia was associated with significantly lower endothelium-dependent flow-mediated dilation compared to controls with low homocysteine levels (6.5% vs 10.8%; P<0.001).
Why the study?
Is hyperhomocysteinemia associated with arterial endothelial dysfunction in asymptomatic healthy adults?
Population
28 asymptomatic, nonsmoking, healthy adult subjects
Comparison
Hyperhomocysteinemia vs Low plasma homocysteine levels
Design
Case-control
Authors
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Hyperhomocysteinemia-linked endothelial impairment may signal early vascular risk; leaves open causality and therapeutic benefit in asymptomatic adults.
Case-Control (n=28)
Is hyperhomocysteinemia associated with arterial endothelial dysfunction in asymptomatic healthy adults?
Absolute Event Rate: 6.5% vs 10.8%
p-value: p=<.001
Hyperhomocysteinemia is independently associated with impaired endothelium-dependent flow-mediated dilation in healthy adults, suggesting a mechanism for its role in premature vascular disease.
Woo et al. (1997) conducted a case-control in Asymptomatic healthy adults (n=28). Hyperhomocysteinemia vs. Low plasma homocysteine levels was evaluated on Endothelium-dependent flow-mediated dilation (EDD) of the brachial artery (p=<.001). Hyperhomocysteinemia was associated with significantly lower endothelium-dependent flow-mediated dilation compared to controls with low homocysteine levels (6.5% vs 10.8%; P<0.001).
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