Key result
Brachial artery administration of nebivolol significantly increased forearm blood flow from 2.76 to 4.40 ml/min/100 ml forearm (P=0.0003), an effect antagonized by L-NMMA.
Why the study?
Does brachial artery administration of nebivolol improve forearm blood flow in patients with essential hypertension?
Population
8 patients with uncomplicated essential hypertension and serum cholesterol <6.9 mmol/L, off antihypertensive…
Comparison
Brachial artery infusion of nebivolol at… vs Baseline blood flow during saline infusion.
Design
Other
Authors
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Small intra-arterial study suggests mechanistic insight; leaves open systemic relevance of nebivolol's nitric oxide effects in hypertension.
Does brachial artery administration of nebivolol improve forearm blood flow in patients with essential hypertension?
Absolute Event Rate: 4.4% vs 2.76%
p-value: p=0.0003
Nebivolol induces vasodilation in the forearm vasculature of patients with essential hypertension, likely via activation of the L-arginine/nitric oxide pathway.
Dawes et al. (1999) studied Essential hypertension (n=8). Nebivolol vs. Baseline (saline) and L-NMMA coinfusion was evaluated on Forearm blood flow (p=0.0003). Brachial artery administration of nebivolol significantly increased forearm blood flow from 2.76 to 4.40 ml/min/100 ml forearm (P=0.0003), an effect antagonized by L-NMMA.
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