Key result
Intracellular sodium activity was 2.9 mM in quiescent rabbit cells; strophanthidin-induced hysteresis between contraction and sodium activity was dramatically reduced under voltage-clamp conditions.
Population
rabbit ventricular myocytes
Comparison
strophanthidin application or removal of… vs baseline/quiescent state
Design
Preclinical
Authors
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Does not inform clinical Na handling; leaves open subsarcolemmal gradients regulating contraction via Na-Ca exchange.
The study suggests that a gradient of sodium concentration from the subsarcolemmal space to the bulk cytoplasm may control calcium influx and contraction via Na-Ca exchange.
Lee et al. (1991) studied Ventricular myocytes (rabbit cells). Strophanthidin was evaluated on Intracellular sodium activity and contraction. Intracellular sodium activity was 2.9 mM in quiescent rabbit cells; strophanthidin-induced hysteresis between contraction and sodium activity was dramatically reduced under voltage-clamp conditions.
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