Key result
Decreases in extracellular Ca2+ concentration yielded marked increases in intracellular Na+ concentration in frog perfused, beating hearts, supporting a crucial role for Na+/Ca2+ exchange.
Why the study?
Does decreasing extracellular Ca2+ concentration affect intracellular Na+ concentration in frog perfused, beating hearts?
Population
Frog intact, perfused, beating hearts
Comparison
Decreases in extracellular Ca2+ concentration… vs Baseline/normal extracellular Ca2+ concentration
Design
Preclinical
Authors
Loading...
Supports Na+/Ca2+ exchange insights from frog models; leaves open translation to mammalian or human myocardium.
Does decreasing extracellular Ca2+ concentration affect intracellular Na+ concentration in frog perfused, beating hearts?
The study demonstrates that decreases in extracellular calcium concentration lead to marked increases in intracellular sodium concentration in frog hearts, supporting the physiological role of Na+/Ca2+ exchange.
POWELL et al. (1990) studied this question. Decreased extracellular Ca2+ concentration was evaluated on Intracellular Na+ concentration ([Na+]i). Decreases in extracellular Ca2+ concentration yielded marked increases in intracellular Na+ concentration in frog perfused, beating hearts, supporting a crucial role for Na+/Ca2+ exchange.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: