Key result
In diabetic rats, potentiation of alpha-adrenoceptor stimulation by halogenated anesthetics is abolished, while beta-adrenoceptor potentiation is preserved with isoflurane and sevoflurane.
In diabetic rat myocardium, isoflurane and sevoflurane preserve the potentiation of beta-adrenoceptor stimulation, whereas halothane does not, likely due to deleterious effects on the sarcoplasmic reticulum.
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Caution against extrapolating diabetic rat findings to human anesthesia; leaves open clinical translation of differential volatile anesthetic effects.
Amour et al. (2004) studied Diabetes mellitus. Halogenated anesthetics (halothane, isoflurane, sevoflurane) vs. Healthy rats was evaluated on Inotropic and lusitropic responses (mean percentage of baseline active force). In diabetic rats, potentiation of alpha-adrenoceptor stimulation by halogenated anesthetics is abolished, while beta-adrenoceptor potentiation is preserved with isoflurane and sevoflurane.
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