Key result
Myocardial work derived from non-invasive left ventricular pressure-strain loops is an advanced tool combining deformation and hemodynamics for evaluating LV systolic function.
Why the study?
Traditional LVEF has fundamental limitations, LV strain is load-dependent, and invasive pressure-volume loops carry procedural risk, prompting the need to describe myocardial work derived from non-invasive LV pressure-strain loops.
Myocardial work derived from non-invasive left ventricular pressure-strain loops provides a novel, load-independent method for evaluating left ventricular systolic function by integrating global longitudinal strain and non-invasive LV systolic pressure.
May aid load-independent LV systolic assessment; leaves open prospective validation before clinical adoption.
The evaluation of left ventricular (LV) systolic function is an essential part of the clinical practice of cardiology. Although left ventricular ejection fraction (LVEF) is the most validated and widely used parameter, it has fundamental limitations. LV strain is more sensitive to detect subtle myocardial dysfunction when LVEF was preserved, but it is load-dependent. Invasive left ventricular pressure-volume loop (LV-PVL) is the reliable standard to evaluate cardiac function, but its wide clinical application is limited by the risk of invasive LV pressure detection. Until the advent of non-invasive LV pressure-strain loop (LV-PSL), things have changed. LV-PSL is in good agreement with regional myocardial oxygen consumption and metabolism. Compared with traditional echocardiographic parameters or LV strain, myocardial work (MW) derived from LV-PSL is a more advanced tool that combines deformation as well as hemodynamics through integration of global longitudinal strain and non-invasive LV systolic pressure. In recent years, researches on MW are going on in full swing and show many advantages of MW. This review described the method and discussed the applications, advantages, limitations, and prospects of MW in multiple cardiovascular diseases. The goal is to provide the readers new insights for evaluating LV systolic function and promote the incorporation of MW into daily practice.
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Li et al. (2022) conducted a review in Cardiovascular diseases. Myocardial work (MW) vs. Traditional echocardiographic parameters or LV strain was evaluated. Myocardial work derived from non-invasive left ventricular pressure-strain loops is an advanced tool combining deformation and hemodynamics for evaluating LV systolic function.
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