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September 1, 2001European Heart JournalOpen Access

Increased plasma endothelin levels in angina patients with rapid coronary artery disease progression

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Why the study?

Are elevated plasma endothelin levels associated with rapid coronary artery disease progression in patients with chronic stable angina?

Population

92 consecutive patients with chronic stable angina pectoris who were on a waiting list for routine coronary…

Comparison

Plasma immunoreactive endothelin levels (exposure) vs Lower plasma endothelin levels

Design

Cohort

Follow-up

5.5+/-3.0 months

Authors

EZEmmanouil Zouridakis

Discussion

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Overview

May identify stable angina patients at risk for rapid progression; leaves open whether endothelin-targeted therapy alters outcomes.

Structured PICO

Are elevated plasma endothelin levels associated with rapid coronary artery disease progression in patients with chronic stable angina?

P
Population
92 consecutive patients (62 men) with chronic stable angina pectoris who were on a waiting list for routine coronary angioplasty
I
Intervention
Plasma immunoreactive endothelin levels (exposure)
C
Comparator
Lower plasma endothelin levels
O
Outcome
Rapid coronary artery disease progression assessed by quantitative angiography between baseline and follow-upsurrogate

Elevated plasma endothelin levels are an independent predictor of rapid coronary artery disease progression in patients with chronic stable angina.

Cite This Study

Emmanouil Zouridakis (2001) studied this question.

synapsesocial.com/papers/6a2302535bf42efd08cb2471https://doi.org/10.1053/euhj.2000.2588
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Raised plasma endothelin in unstable angina and non-Q wave myocardial infarction: relation to cardiovascular outcome.1994 · 75 citations
  2. 2Concentration of circulating plasma endothelin in patients with angina and normal coronary angiograms.1995 · 120 citations
  3. 3Prognostic significance of progression of coronary atherosclerosis.1993 · 277 citations
  4. 4Local Changes in the Plasma Endothelin Level in the Coronary Artery Immediately after Percutaneous Transluminal Coronary Angioplasty2008 · 7 citations
  5. 5Prognostic value of plasma endothelin-1 in patients with chronic heart failure1997 · 238 citations