Why the study?
Does percutaneous transluminal coronary angioplasty alter local plasma endothelin levels in the coronary circulation?
Population
Patients undergoing percutaneous transluminal coronary angioplasty (PTCA)
Comparison
Percutaneous transluminal coronary angioplasty vs Pre-angioplasty levels and peripheral vein levels
Design
Cohort
Follow-up
Immediately after the procedure
Key result
Percutaneous transluminal coronary angioplasty did not significantly alter local coronary endothelin levels, which remained higher than peripheral venous levels (9.8 vs 7.7 pg/ml, P<0.005).
Authors
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Endothelin changes after PTCA remain uncharacterized in this Level 5 report; leaves open any clinical or therapeutic implications.
Observational
Does percutaneous transluminal coronary angioplasty alter local plasma endothelin levels in the coronary circulation?
Absolute Event Rate: 9.8% vs 7.7%
p-value: p=<0.005
PTCA does not acutely alter local coronary endothelin levels on average, although baseline coronary levels are significantly higher than peripheral venous levels.
ek et al. (2008) conducted an observational in Coronary artery disease requiring PTCA. Percutaneous transluminal coronary angioplasty (PTCA) vs. Peripheral vein was evaluated on Plasma endothelin level (p=<0.005). Percutaneous transluminal coronary angioplasty did not significantly alter local coronary endothelin levels, which remained higher than peripheral venous levels (9.8 vs 7.7 pg/ml, P<0.005).
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