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January 1, 2000Catheterization and Cardiovascular Interventions

Release of endothelin 1 and angiotensin II induced by percutaneous transluminal coronary angioplasty

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Why the study?

Does percutaneous transluminal coronary angioplasty induce the release of vasoactive substances and markers of endothelial injury compared to diagnostic angiography in patients with ischemic heart disease?

Population

44 patients with ischemic heart disease undergoing elective percutaneous transluminal coronary angioplasty…

Comparison

Percutaneous transluminal coronary angioplasty… vs Diagnostic coronary angiography (n=7).

Design

Cohort

Follow-up

24 hours

Authors

YHYukihiro HojoUIUichi IkedaTKTaka-aki Katsuki

Discussion

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Member takes

Overview

Suggests PTCA induces endothelial injury irrespective of technique; leaves open whether changes exceed diagnostic angiography or affect outcomes.

Structured PICO

Does percutaneous transluminal coronary angioplasty induce the release of vasoactive substances and markers of endothelial injury compared to diagnostic angiography in patients with ischemic heart disease?

P
Population
44 patients with ischemic heart disease undergoing elective percutaneous transluminal coronary angioplasty (PTCA) to isolated stenotic lesions in left coronary arteries, and 7 control subjects undergoing diagnostic coronary angiography.
I
Intervention
Percutaneous transluminal coronary angioplasty (PTCA), including balloon angioplasty (n=11), percutaneous transluminal rotational atherectomy (n=14), or stent implantation (n=19).
C
Comparator
Diagnostic coronary angiography (n=7).
O
Outcome
Plasma levels of endothelin (ET) 1, angiotensin (ANG) II, von Willebrand factor (vWF), and thrombomodulin (TM) in coronary sinus blood immediately before and after, 4 hours, and 24 hours after the procedure.surrogate

PTCA induces coronary endothelial injury, reflected by the release of ET-1, ANG II, and vWF into the coronary sinus, regardless of the specific interventional modality used.

Cite This Study

Hojo et al. (2000) studied this question.

synapsesocial.com/papers/6a8c3aca7220baec05bbb87dhttps://doi.org/10.1002/1522-726x(200009)51:1<42::aid-ccd10>3.0.co;2-a
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