Key result
In the dog heart in vivo, ISF infusion of Ang I + captopril reduced Ang II levels more than Ang I + chymostatin (71% vs 43%, P<0.01), while combining both inhibitors produced a 100% decrease.
Why the study?
Does ACE and chymase inhibition reduce Angiotensin II formation in the interstitial fluid space of the dog heart in vivo?
Does ACE and chymase inhibition reduce Angiotensin II formation in the interstitial fluid space of the dog heart in vivo?
Absolute Event Rate: 71% vs 43%
p-value: p=<0.01
Both ACE and chymase mediate a very high capacity for conversion of Ang I to Ang II in the interstitial fluid space of the heart in vivo.
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Hypothesis-generating in dogs; leaves open dual ACE/chymase contributions to cardiac Ang II in humans.
Wei et al. (1999) studied Normal dogs (animal model) (n=12). ISF infusion of Ang I with captopril and/or chymostatin vs. ISF infusion of Ang I alone was evaluated on Reduction in ISF Ang II levels (p=<0.01). In the dog heart in vivo, ISF infusion of Ang I + captopril reduced Ang II levels more than Ang I + chymostatin (71% vs 43%, P<0.01), while combining both inhibitors produced a 100% decrease.
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