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September 1, 1994Journal of neurosurgery

Cell membrane potential depolarized to -30.9 mV at pH 7.65 and hyperpolarized to -58.4 mV at pH 6.8 from a baseline of -37.5 mV at pH 7.3, demonstrating a linear relationship with vessel diameter.

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Population

Isolated rat cerebral arterioles ranging from 44 to 91 microns in diameter

Comparison

Extravascular pH alteration and perfusion with… vs Baseline pH 7.3

Design

Preclinical

Authors

HDHans H. DietrichRDRalph G. Dacey

Discussion

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Overview

pH effects on arteriolar membrane potential warrant in vivo validation; leaves open translation to human cerebral vasoregulation.

Structured PICO

P
Population
Isolated rat cerebral arterioles ranging from 44 to 91 microns in diameter
I
Intervention
Extravascular pH alteration (pH 7.65 or 6.8) and perfusion with 70 mM KCl
C
Comparator
Baseline pH 7.3
O
Outcome
Cell membrane potential and vessel diametersurrogate

Extravascular pH alterations linearly affect cell membrane potential and vessel diameter in isolated rat cerebral arterioles, providing the first in vitro measurements of these membrane potentials.

Cite This Study

Dietrich et al. (1994) studied this question.

synapsesocial.com/papers/6a2304eec650520b07cb27f1https://doi.org/10.3171/jns.1994.81.3.0437
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Also Consider

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  1. 1Flash Photolysis Studies of Excitation-Contraction Coupling, Regulation, and Contraction in Smooth Muscle1990 · 99 citations
  2. 2Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog.1987 · 118 citations