Key result
An increase in body mass index over 3 years was associated with a decrease in physical health-related quality of life (b -0.09 per 1 kg/m2), particularly in women and obese individuals.
Why the study?
Does change in BMI affect health-related quality of life in high-risk cardiovascular primary care patients?
Cohort (n=6,726)
Yes
Does change in BMI affect health-related quality of life in high-risk cardiovascular primary care patients?
Mean Difference: -0.09 (95% CI -0.15–-0.03)
p-value: p=0.004
Increases in BMI are associated with decreased physical quality of life, particularly in women and obese individuals, but increased mental quality of life over time in high-risk cardiovascular patients.
OBJECTIVE: Health-related quality of life (HRQoL) is an important outcome in individuals with a high risk for cardiovascular diseases. We investigated the association of HRQoL and body mass index (BMI) as an indicator for obesity. DESIGN: Secondary longitudinal analysis of the ORBITAL study, an intervention study which included high-risk cardiovascular primary care patients with hypercholesterolemia and an indication for statin therapy. METHODS: HRQoL was determined with the generic Short Form (SF)-12 health status instrument. Body weight and height were assessed at baseline and at months 6, 12, 18, 24, 30, and 36. We used a linear and a linear mixed-effects regression model to investigate the association between BMI and SF-12 summary scores at baseline as well as between change in BMI and SF-12 summary scores over 3 years. We adjusted for age, sex, smoking status, and in the longitudinal analysis also for the study arm and its interaction term with time. RESULTS: Of the 7640 participants who completed the baseline questionnaire, 6726 participants (mean age: 61 years) were analyzed. The baseline BMI was inversely associated with physical and mental SF-12 summary scores (β [95% CI] per 1 kg/m2: -0.36 [-0.41; -0.30] and -0.05 [-0.11; -0.00], respectively). A significant association between the change in BMI and physical SF-12 summary scores over time was only present in women (-0.18 [-0.27; -0.09]) and only in obese participants (-0.19 [-0.29; -0.10]). A change in BMI was directly associated with mental SF-12 summary scores (0.12 [0.06; 0.19]) in the total population. CONCLUSION: Increases in BMI were associated with decreases in physical HRQoL, particularly in obese individuals and in women. In contrast, the mental HRQoL seemed to increase with increasing BMI over time. Thus, body weight management with respect to the HRQoL should be evaluated differentially by sex and body weight status. TRIAL REGISTRATION: ClinicalTrials.gov NCT00379249.
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Müller‐Nordhorn et al. (2014) conducted a cohort in Hypercholesterolemia with high cardiovascular risk (n=6,726). Change in body mass index vs. Stable body mass index was evaluated on Change in physical SF-12 summary score per 1 kg/m2 increase in BMI over 3 years (b -0.09, 95% CI -0.15; -0.03, p=0.004). An increase in body mass index over 3 years was associated with a decrease in physical health-related quality of life (b -0.09 per 1 kg/m2), particularly in women and obese individuals.
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