Key result
Graded leg cycling amplified the respiratory modulation of sympathetic vasomotor outflow, with MSNA burst frequency being lowest at end-inspiration and highest at mid-to-end expiration.
Why the study?
It was unknown whether respiratory modulation of sympathetic vasomotor outflow to skeletal muscle persists during dynamic whole body exercise.
Does respiratory modulation of sympathetic vasomotor outflow persist during dynamic whole body exercise in humans?
Observational
Does respiratory modulation of sympathetic vasomotor outflow persist during dynamic whole body exercise in humans?
Respiratory modulation of sympathetic vasomotor outflow remains intact and is amplified during dynamic whole body exercise.
Respiratory-sympathetic coupling during exercise merits consideration in autonomic testing; leaves open clinical relevance in cardiovascular disease.
Within-breath modulation of sympathetic vasomotor outflow to skeletal muscle (muscle sympathetic nerve activity; MSNA) occurs in spontaneously breathing humans at rest. It is unknown if respiratory modulation persists during dynamic whole body exercise. We found that MSNA burst frequency was lowest at end-inspiration and highest at mid-to-end expiration during rest and graded leg cycling. Respiratory modulation of sympathetic vasomotor outflow remains intact and is amplified during dynamic whole body exercise.
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Katayama et al. (2021) reported an observational. Graded leg cycling vs. Rest was evaluated on Muscle sympathetic nerve activity (MSNA) burst frequency. Graded leg cycling amplified the respiratory modulation of sympathetic vasomotor outflow, with MSNA burst frequency being lowest at end-inspiration and highest at mid-to-end expiration.
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